Medical Articles
Only plasma exchange therapy and IV immune serum globulin have proven effective. Both therapies have been shown to shorten recovery time by as much as 50%. The cost, difficulty, and efficacy of the two treatments are comparable.
Corticosteroids are ineffective as monotherapy. Evidence suggests that no benefit exists in giving steroids in combination with IV immunoglobulins or in combination with plasma exchange.
Deep vein thrombosis (DVT) prophylaxis with subcutaneous low molecular weight heparin (LMWH) may cause a dramatic reduction in the incidence of venous thromboembolism, one of the major sequelae of extremity paralysis.
Blood product derivatives are used to improve the clinical and immunologic aspects of the disease. They may decrease autoantibody production and increase solubilisation and removal of immune complexes.
Intravenous immune globulin (IVIG, Gammagard S/DAY) are these American brand names? may neutralise circulating myelin antibodies through anti-idiotypic antibodies and down-regulate proinflammatory cytokines, including interferon-gamma (INF-gamma). In addition, may block the complement cascade and promote remyelination. Dosage: 0.4 g/kg/day IV for 5 day.
Albumin is used in plasma exchange when the patient's plasma is exchanged with a plasma substitute. It may remove autoantibodies and immune complexes from serum. Plasma exchange is carried out with albumin (50 mL/kg) over a 10-day period. Has been shown to decrease recovery time by 50%. May aid in removing cytotoxic constituents from serum. Remove 3-4 L of the patient's plasma and substitute with albumin, administered IV.
Physical therapy and occupational therapy may be beneficial in helping patients to regain their baseline functional status.
Pre-hospital care
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