Mechanism of action
Typhoid Vaccine, USP is a saline suspension containing not more than 1000 million Salmonella typhosa (Ty-2 strain) organisms per mL. After growing on veal infusion agar (containing 0.5 percent sodium chloride, 2 percent peptone, and 5 percent agar), the bacteria are washed off the medium, suspended in buffered sodium chloride injection, and killed by a combination of phenol and heat. Phenol (0.5 percent) is added to the final vaccine as preservative.