Mechanism of action
Endocrine System: After binding to the receptor, the steroid – receptor complex binds to chromatin and stimulates the formation of mRNA. The mRNA stimulates the synthesis of enzymes. The anti-inflammatory action is due to inhibition of prostaglandin and leukotriene synthesis. The actions of glucocorticoids are
increased gluconeogenesis.increased lipolysisincreased liver stores of glycogen CNS effects, euphoriaincreased haemoglobin synthesisrestrict capillary permeability and maintenance of cardiovascular functioncause normal skeletal muscular functionanti-inflammatory actionsuppression of immune responsestabilize lysosomal membranesantiallergic action.