Tolbutamide is one of the most widely used antidiabetic agents. Its action is preferably connected with stimulatory action of β-cells in the pancreas, which results in intensive insulin secretion. It is used for type II diabetes mellitus of medium severity with no expressed microvascular complications.
It is classified as first generation sulphonylurea; a sole action being lowering of blood glucose levels in normal and non-insulin dependent diabetics, but not insulin dependent diabetics, its mechanism of action is like glibenclamide.
It is classified as first generation sulphonylurea; a sole action being lowering of blood glucose levels in normal and non-insulin dependent diabetics, but not insulin dependent diabetics, its mechanism of action is like glibenclamide.
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