Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis.
It is a bactericidal drug and exerts its action by combining with bacterial ribosome and induces misreading of mRNA codons. Also in sensitive bacteria, disruption of cytoplasmic membrane occurs resulting in leakage of amino acids, ions, leading to bacterial death.
It is a bactericidal drug and exerts its action by combining with bacterial ribosome and induces misreading of mRNA codons. Also in sensitive bacteria, disruption of cytoplasmic membrane occurs resulting in leakage of amino acids, ions, leading to bacterial death.
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