Mechanism of action
After binding to the receptor, the steroid – receptor complex binds to chromatin and stimulates the formation of mRNA. The mRNA stimulates the synthesis of enzymes. The anti-inflammatory action is due to inhibition of prostaglandin and leukotriene synthesis. The actions of Prednisolone are
increased gluconeogenesisincreased lipolysisincreased liver stores of glycogenCNS effects, euphoriaincreased haemoglobin synthesisRestrict capillary permeability and maintenance of cardiovascular functioncause normal skeletal muscular functionsanti-inflammatory actionsuppression of immune responsestabilize lysosomal membranesanti allergic action.