Sodium cromoglycate is a widely used drug for the prevention of allergic diseases, especially in bronchial asthma and allergic rhinitis. It inhibits mastocyte degranulation and has a direct effect on inflammatory cells and the bronchial obstructive reflex.
Precise mechanism of action is uncertain. It has several properties like phosphodiesterase inhibition, reduction of alpha-adrenoreceptor density, inhibition of IgE-dependant mediator secretion by cell types other than mast cells, which have been proposed to account for its activity in asthma inhibition.
Precise mechanism of action is uncertain. It has several properties like phosphodiesterase inhibition, reduction of alpha-adrenoreceptor density, inhibition of IgE-dependant mediator secretion by cell types other than mast cells, which have been proposed to account for its activity in asthma inhibition.
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