It is a semi-synthetic derivative of lovastatin, the first FDA-approved statin. Simvastatin helps lower cholesterol production and reduce dyslipidemia-associated complications. High concentrations of LDL cholesterol can lead to artery damage, potentially leading to cardiac complications and stroke.
HMGCoA reductase inhibitors block the synthesis of cholesterol in liver by competitively inhibiting HMGCoA reductase activity, also cause depletion of critical intracellular pools of sterols and increased transcription of LDL receptors leading to enhanced removal from plasma of LDL and LDL precursors.
HMGCoA reductase inhibitors block the synthesis of cholesterol in liver by competitively inhibiting HMGCoA reductase activity, also cause depletion of critical intracellular pools of sterols and increased transcription of LDL receptors leading to enhanced removal from plasma of LDL and LDL precursors.
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