Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly
Sildenafil induces erections in response to sexual stimulation by causing smooth muscle relaxation in the corpus cavernosum through selective inhibition of phosphodiesterase type 5 (PDE5). Since sildenafil only lowers the inactivation of cyclic guanosine monophosphate (cGMP) and does not enhance its production, penile erection due to sildenafil is achieved only in response to sexual stimulation.
Sildenafil induces erections in response to sexual stimulation by causing smooth muscle relaxation in the corpus cavernosum through selective inhibition of phosphodiesterase type 5 (PDE5). Since sildenafil only lowers the inactivation of cyclic guanosine monophosphate (cGMP) and does not enhance its production, penile erection due to sildenafil is achieved only in response to sexual stimulation.
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