Penfluridol is an unusual, potent, long-acting, first-generation, oral antipsychotic agent indicated for the treatment of chronic schizophrenia, acute psychosis, and Tourette syndrome. It may be considered a depot medication, as it is administered once a week.
Penfluridol is an antipsychotic drug that inhibits SIRT1, and peroxisome proliferator activated receptor co activator 1-α (PGC-1α), therefore inhibiting the mitochondrial oxidative phosphorylation whereas inducing glycolysis to compensate the energy depletion.
Penfluridol is an antipsychotic drug that inhibits SIRT1, and peroxisome proliferator activated receptor co activator 1-α (PGC-1α), therefore inhibiting the mitochondrial oxidative phosphorylation whereas inducing glycolysis to compensate the energy depletion.
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