PABA and PABA derivatives are commonly used in sunscreens as ultraviolet B (UVB) filters. PABA use has declined over the years, but its derivatives are still around today. PABA may alter thyroid activity,, and PABA derivatives may have additional endocrine disrupting properties.
Sulfonamides are structural analogs of para-aminobenzoic acid (PABA) and thus act as competitive antagonists in microbial cells. Microbes need PABA to form dihydrofolic acid, a precursor of folic acid. Folic acid is required for purine and pyrimidine synthesis and hence nucleic acid synthesis.
Sulfonamides are structural analogs of para-aminobenzoic acid (PABA) and thus act as competitive antagonists in microbial cells. Microbes need PABA to form dihydrofolic acid, a precursor of folic acid. Folic acid is required for purine and pyrimidine synthesis and hence nucleic acid synthesis.
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