Mechanism of action
Orphenadrine acts in the central nervous system (CNS) to produce its muscle relaxant effects. Orphenadrine also has other actions (anticholinergic) that produce its helpful effects in Parkinson’s disease.binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. Orphenadrine’s CNS and anticholinergic actions may also be responsible for some of its side effects.