Mechanism of action
Oestrogens act by binding to nuclear oestrogen receptors. After activation oestrogen receptors bind to specific DNA sequences (hormone response elements) that enhance the transcription of adjacent genes.
Medical Articles
Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
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