Nafarelin acetate is a potent agonistic analog of gonadotropin-releasing hormone (GnRH). At the onset of administration, nafarelin stimulates the release of the pituitary gonadotropins, LH and FSH, resulting in a temporary increase of ovarian steroidogenesis.
It is rapidly absorbed into the systemic circulation following intra-nasal delivery. It stimulates the release of LH and FSH from the anterior pituitary resulting in a temporary increase of ovarian steroidogenesis. After 2-3 days of daily administration, the pituitary becomes refractory to further stimulation. LH/FSH release is inhibited within 10 days and is followed by a decrease in secretion of gonadal steroids within 2-6 weeks.
It is rapidly absorbed into the systemic circulation following intra-nasal delivery. It stimulates the release of LH and FSH from the anterior pituitary resulting in a temporary increase of ovarian steroidogenesis. After 2-3 days of daily administration, the pituitary becomes refractory to further stimulation. LH/FSH release is inhibited within 10 days and is followed by a decrease in secretion of gonadal steroids within 2-6 weeks.
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