Mechanism of action
Exerts potent presynaptic central a2 adrenergic blocking activity which may cause increased noradrenaline release. It does not affect Na or 5HT uptake in CNS.
Medical Articles
Mianserin is a quadricyclic compound with complex pharmacological actions. It has weak noradrenaline reuptake inhibiting effects, and is a fairly potent antagonist at a number of neurotransmitter receptors, including serotonin2, serotonin3, and noradrenergic α1- and α2-adrenoceptors.
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