Menadione acts as a vitamin K analogue, acting as a cofactor in the synthesis of Factor II, VII, IX, X in the liver. The Vitamin K analogue is needed in the step of gamma carboxylation of these factors which renders them capable of binding ca ions to phospholipid surfaces which is essential for the coagulation…
It is necessay for final stage of synthesis of coagulation factors : II, VII, IX and X in liver. In synthesis of coagulant proteins Vit. K is converted to an epoxide which is subsequently reduced to active Vit. K.
It is necessay for final stage of synthesis of coagulation factors : II, VII, IX and X in liver. In synthesis of coagulant proteins Vit. K is converted to an epoxide which is subsequently reduced to active Vit. K.
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