Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart.
Losartan and its principle active metabolite block the vasoconstrictor & aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptors found in vascular smooth muscle, adrenal gland etc.
Losartan and its principle active metabolite block the vasoconstrictor & aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptors found in vascular smooth muscle, adrenal gland etc.
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