Medical Articles

Lixisenatide

Hypoglycaemic agents

Description

Lixisenatide is a glucagon-like peptide-1 (GLP-1) analogue (also called a GLP-1 receptor agonist) that acts like the native gastrointestinal hormone (incretin) to increase insulin secretion.

Mechanism of action

It is an incretin mimic that acts as an agonist at glucagon-like peptide 1 (GLP-1) receptor. It increases glucose-dependent insulin secretion by the pancreatic β-cells, suppresses inappropriately elevated glucagon secretion, increases β-cell growth/replication, and slows gastric emptying. It also decreases food intake by reducing appetite and increasing satiety.

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Mechanism of action

It is an incretin mimic that acts as an agonist at glucagon-like peptide 1 (GLP-1) receptor. It increases glucose-dependent insulin secretion by the pancreatic β-cells, suppresses inappropriately elevated glucagon secretion, increases β-cell growth/replication, and slows gastric emptying. It also decreases food intake by reducing appetite and increasing satiety.

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