Levodpa and Carbidopa treats the symptoms of Parkinson disease. It works by increasing the amount of dopamine in your brain, a substance which helps manage body movements and coordination. This reduces the symptoms of Parkinson, such as body stiffness and tremors.
In Parkinson’s disease there is depletion of dopamine in dopaminergic neurons in striatum. Levodopa is decarboxylated to dopamine by dopa decarboxylase in brain. In hypokinesia, rigidity are controlled earlier and tremors later on. Carbidopa : Acts by inhibiting peripheral dopa decarboxylase enzyme, therefore conversion of levodopa to dopamine is inhibited. Hence low dose of levodopa is required.
In Parkinson’s disease there is depletion of dopamine in dopaminergic neurons in striatum. Levodopa is decarboxylated to dopamine by dopa decarboxylase in brain. In hypokinesia, rigidity are controlled earlier and tremors later on. Carbidopa : Acts by inhibiting peripheral dopa decarboxylase enzyme, therefore conversion of levodopa to dopamine is inhibited. Hence low dose of levodopa is required.
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