Furosemide belongs to a group of medicines called loop diuretics (also known as water pills). Furosemide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions
The inhibitors of Na+-K- -2Cl symport bind to the Na+-K- -2Cl symporter in the thick ascending limb and block its function, bringing the salt transport to virtual standstill. It also inhibits Ca+ and Mg+ reabsorption in ascending limb by abolishing the transepithelial potential difference.
The inhibitors of Na+-K- -2Cl symport bind to the Na+-K- -2Cl symporter in the thick ascending limb and block its function, bringing the salt transport to virtual standstill. It also inhibits Ca+ and Mg+ reabsorption in ascending limb by abolishing the transepithelial potential difference.
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