Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, though it is no more potent a neuroleptic than other agents (e.g. haloperidol), which are D2 antagonists only (Ehmann 1987). It blocks prolactin inhibitory factor (PIF), resulting in an increase in pituitary prolactin secretion
It exerts weak anticholinergic and adrenergic effects. It possesses antiemetic actions. As flupentixol works by antagonizing dopamine actions, it can cause extrapyramidal effects, 11 mostly at doses greater than 10 mg.
It exerts weak anticholinergic and adrenergic effects. It possesses antiemetic actions. As flupentixol works by antagonizing dopamine actions, it can cause extrapyramidal effects, 11 mostly at doses greater than 10 mg.
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