Mechanism of action
The mechanism by which it exerts its action is not completely known. It inibits bone resorption.
Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption. Unlike other bisphosphonates, etidronate may also prevent bone calcification
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