Ergot alkaloids are potent α-blockers that cause direct smooth muscle contraction. They are products of the fungus Claviceps purpurea. Only products of lysergic acid are of clinical importance. Ergotamine has a 100% first-pass metabolism and hence its derivatives, ergonovine and methyl ergonovine, are commonly used.
Ergot alkaloids have structures similar to the biogenic amines norepinephrine, serotonin and dopamine. Vasoconstriction is produced by an agonist activity and this effect varies with different vascular beds. Hyperthermia and uterine stimulation are other effects.
Ergot alkaloids have structures similar to the biogenic amines norepinephrine, serotonin and dopamine. Vasoconstriction is produced by an agonist activity and this effect varies with different vascular beds. Hyperthermia and uterine stimulation are other effects.
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