Eplerenone belongs to the general class of medicines called antihypertensives. It is used alone or together with other medicines to treat high blood pressure (hypertension). This medicine is also used to treat congestive heart failure (CHF) after a heart attack.
It is a selective aldosterone receptor antagonist. It binds to the mineralocorticoid receptor and blocks binding of aldosterone. Aldosterone synthesis occurs in adrenal gland and is modulated by angiotensin II, ACTH & potassium. Aldosterone binds to mineralocorticoid receptor and increases blood pressure. Eplerenone has relative selectivity in binding to human mineralocorticoid receptors compared to its binding to glucocorticoid and androgen receptors.
It is a selective aldosterone receptor antagonist. It binds to the mineralocorticoid receptor and blocks binding of aldosterone. Aldosterone synthesis occurs in adrenal gland and is modulated by angiotensin II, ACTH & potassium. Aldosterone binds to mineralocorticoid receptor and increases blood pressure. Eplerenone has relative selectivity in binding to human mineralocorticoid receptors compared to its binding to glucocorticoid and androgen receptors.
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