Mechanism of action
Selective antagonist of neurokinin 1 and 3 receptors in hypothalamus; blocks KNDy (kisspeptin/neurokinin B/dynorphin) neuron signaling that regulates core body temperature and thermoregulatory set point.
Medical Articles
First-in-class dual NK1/NK3 receptor antagonist approved for treatment of moderate-to-severe vasomotor symptoms (hot flashes) associated with menopause.
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© 2025 The Doctors Platform. All Right Reserved.