It has been noted that ornithine decarboxylase (ODC) exhibits high activity in tumor cells, promoting cell growth and division, while absence of ODC activity leads to depletion of putrescine, causing impairment of RNA and DNA synthesis. Hence thought to be anti cancer drug. eflornithine has replaced melarsoprol as the first line medication against Human African…
Eflornithine appears to kill trypanosomes by acting as a suicide inhibitor of the enzyme ornithine decarboxylase, this enzyme regulates cell division by catalysing the first step in polyamine biosynthesis.
Eflornithine effects against Trypanosoma brucei gambiense were discovered by chance and because its ability to bring patients back from the coma, it became known as “Resurrection Drug”.
Eflornithine appears to kill trypanosomes by acting as a suicide inhibitor of the enzyme ornithine decarboxylase, this enzyme regulates cell division by catalysing the first step in polyamine biosynthesis.
Eflornithine effects against Trypanosoma brucei gambiense were discovered by chance and because its ability to bring patients back from the coma, it became known as “Resurrection Drug”.
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