Medical Articles

Dopamine

Drugs used in cardiac failure & shock

Description

Dopamine is a chemical released in the brain that makes you feel good. Having the right amount of dopamine is important both for your body and your brain. Dopamine helps nerve cells to send messages to each other.

Mechanism of action

It is an agonist for dopamine receptors in CNS, renal and other vascular beds (vasodilator). It is an immediate metabolic precursor of norepinephrine. Dopamine is an agonist at 1 adrenoceptors in heart. At high doses it stimulates alpha adrenoceptors leading to vasoconstriction. I.V. infusion of dopamine in low doses is associated with increased renal blood flow, increased GFR and sodium excretion.

 

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Mechanism of action

It is an agonist for dopamine receptors in CNS, renal and other vascular beds (vasodilator). It is an immediate metabolic precursor of norepinephrine. Dopamine is an agonist at 1 adrenoceptors in heart. At high doses it stimulates alpha adrenoceptors leading to vasoconstriction. I.V. infusion of dopamine in low doses is associated with increased renal blood flow, increased GFR and sodium excretion.

 

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