Diphenoxylate is an active ingredient of commonly available antimotility agents. Its indication is for the treatment of diarrhea in adults and children 13 years or older or as add-on therapy in managing acute non-infectious diarrhea.
Diphenoxylate is an opiate receptor agonist that stimulates muscarinic receptors in GI, decreases the peristalsis and constricts the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel and prolongs gastrointestinal transit time.
Diphenoxylate is an opiate receptor agonist that stimulates muscarinic receptors in GI, decreases the peristalsis and constricts the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel and prolongs gastrointestinal transit time.
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