Dalteparin is a blood thinner. It helps to prevent complications related to unstable angina (chest pain) or heart attack.It is used as a prophylaxis for deep-vein thrombosis and pulmonary embolisms in patients undergoing general surgery (e.g., abdominal, gynecologic, urologic), and in patients with acute medical conditions (e.g. cancer, bed rest, heart failure, severe lung disease)
The antithrombotic effect of dalteparin sodium is dependent on its ability to potentiate the inhibition of factor Xa and thrombin by antithrombin {AT}. It has a relatively higher ability to potentiate factor Xa inhibition than to prolong plasma clotting time {APTT}. It has a smaller effect on platelet function and platelet adhesion than heparin, and thus has only a small effect on primary homeostasis.
The antithrombotic effect of dalteparin sodium is dependent on its ability to potentiate the inhibition of factor Xa and thrombin by antithrombin {AT}. It has a relatively higher ability to potentiate factor Xa inhibition than to prolong plasma clotting time {APTT}. It has a smaller effect on platelet function and platelet adhesion than heparin, and thus has only a small effect on primary homeostasis.
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