Mechanism of action
“Cloxacillin is bactericidal and act by
interfering with bacterial cell wall synthesis. Certain generalizations are
useful for penicillins. After administration penicillins are widely
distributed throughout body and therapeutic concentration is achieved in
tissues and secretions such as pericardial fluid, pleural fluid, bile and
joint fluid. Low concentration of these drugs is found in brain tissue,
prostatic secretions and intraocular fluid. Penicillins are excreted fast by
the kidney, hence have short plasma half-life. Blood levels of all
penicillins can be raised by administration of Probenecid. Do not treat
severe pneumonia, bacteraemia, meningitis, empyema, pericarditis or septic
arthritis with oral penicillin during the acute stage. In case of history of
allergy to Penicillin, they are contraindicated for use.”