Mechanism of action
Bactericidal by interfering with bacterial cell wall synthesis. After administration Bacampicillin are widely distributed throughout body and therapeutic concentration is achieved in tissues and secretions such as pericardial fluid, pleural fluid, bile and joint fluid. Low concentrations of these drugs are found in brain tissue, prostatic secretions and intraocular fluid. Bacampicillin are excreted fast by the kidney, hence have short plasma half life. Blood levels of all Bacampicillins can be raised by administration of Probenecid. Do not treat severe pneumonia, bacteraemia, meningitis, empyema, pericarditis or septic arthritis with oral penicillin during the acute stage. In case of history of allergy to Penicillin, they are contraindicated for use.