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Clinical Disciplines

Neurology
Mental Retardation

Prognosis

Prognosis

Poor prognosis is associated with rapid progression of symptoms, advanced age, prolonged ventilation (1 mo), and severe reduction of action potentials on neuromuscular testing.

Published reports indicate full recovery may be expected in 50-95% of cases.

Neurologic sequelae:

  • Reported incidence of permanent neurologic sequelae ranges from 10-40%.
  • The worst-case scenario is tetraplegia within 24 hours with incomplete recovery after 18 months or longer.
  • The best-case scenario is mild difficulty walking, with recovery within weeks.
  • The usual scenario is peak weakness in 10-14 days with recovery in weeks to months. Average time on a ventilator (without treatment) is 50 days.

Mortality:

  • Most is due to severe autonomic instability or from the complications of prolonged intubation and paralysis.
  • Mortality rates range from 5-10%.

Prognosis

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