Sodium antimony gluconate has been shown to induce nitric oxide synthesis (NO) and reactive oxygen species (ROS), with both ROS and NO involved in parasite killing in the early stage of infection and NO in the late stage.
It is a drug of choice for Kala-azar, its mechanism of action is unclear. Probably its enzyme causes inhibition and interferes with the bioenergetics of the parasites. It blocks the glycolic and fatty acid oxidation pathways.
It is a drug of choice for Kala-azar, its mechanism of action is unclear. Probably its enzyme causes inhibition and interferes with the bioenergetics of the parasites. It blocks the glycolic and fatty acid oxidation pathways.
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