Mechanism of action
The main action of Ramipril is to inhibit conversion of angiotensin I (inactive) to angiotensin II (active). Inhibits the converting enzyme. Hence, angiotensin II production is inhibited. The drug has several advantages. It does not have direct sympatholytic activity. Hence, cardiovascular reflexes are intact and postural hypotension is rare. They can be administered in patients of hypertension with diabetes mellitus or bronchial asthma. It can be administered safely. Ramipril is efficacious drug, is well tolerated and is useful antihypertensive drug.