Mechanism of action
Have detergent like action on cell membrane. Have high affinity for phospholipids, penetrate into and disrupt the structure of cell membranes, as a result of which amino acids and ions leak out.
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. While it is useful for many Gram negative infections, it is not useful for Gram positive infections.
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