Mefloquine is a long-acting blood schizontocide with high efficacy against malarial parasites resistant to quinine, chloroquine and sulphonamide-pyrimethamine combinations . A single oral dose of the drug of 15 mg/kg (with a maximum of 750-1000 mg/adult) produces cure rates above 90%.
Exact mechanism of action is unknown. It behaves like quinine in many ways but does not inhibit haem polymerase. It probably acts by forming toxic complexes with free haem that damages membranes and interacts with other plasmodial components.
Exact mechanism of action is unknown. It behaves like quinine in many ways but does not inhibit haem polymerase. It probably acts by forming toxic complexes with free haem that damages membranes and interacts with other plasmodial components.
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