It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite. Metoclopramide is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD)
Centrally acting dopamine antagonis acts on chemoreceptor trigger zone. Causes forward propulsion of contents of stomach. It also acts peripherally to enhance the effect of acetyl choline at muscarinic receptors in gut.
Centrally acting dopamine antagonis acts on chemoreceptor trigger zone. Causes forward propulsion of contents of stomach. It also acts peripherally to enhance the effect of acetyl choline at muscarinic receptors in gut.
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