Mechanism of action
It acts by blocking fast sodium channels, reducing the phase 0 maximal upstroke velocity of the action potential.
Medical Articles
Mexiletine is an oral medication that blocks sodium channels in cardiac myocytes and nerve cells. In cardiac myocytes, mexiletine affects phase 0 of the cardiac myocyte action potential, inhibiting the inward sodium current, and its mechanism of action can be generalized across all Class 1B antiarrhythmics.
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