Milrinone is a medication indicated for cardiac support in patients with acute heart failure, pulmonary hypertension, or chronic heart failure. It is often used during cardiac surgeries, including coronary artery bypass graft surgery, cardiac transplantation, and other cardiac surgeries requiring cardiac support.
It is a relatively selective inhibitor of peak III cyclic AMP phosphodiesterase isozyme in cardiac and vascular muscle. In patients with CHF, it produces dose related and plasma drug concentration related increases in the maximum rate of increase of left ventricular pressure. Milrinone has a direct inotropic and direct arterial vasodilator activity.
It is a relatively selective inhibitor of peak III cyclic AMP phosphodiesterase isozyme in cardiac and vascular muscle. In patients with CHF, it produces dose related and plasma drug concentration related increases in the maximum rate of increase of left ventricular pressure. Milrinone has a direct inotropic and direct arterial vasodilator activity.
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