Medical Articles

Artesunate

Anti malarials

Description

An artemisinin derivative that is metabolized to DHA, which generates free radicals to inhibit normal function of Plasmodium

Mechanism of action

It is concentrated in parasitized erythrocytes,
where it is activated by parasite haem, generating free radicals. Hence it
causes increase in oxidant stress on the infected red cells promoting
cytotoxicity and death of parasites. It rapidly clears parasitaemia, faster
than any other antimalarial drug.

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Mechanism of action

It is concentrated in parasitized erythrocytes,
where it is activated by parasite haem, generating free radicals. Hence it
causes increase in oxidant stress on the infected red cells promoting
cytotoxicity and death of parasites. It rapidly clears parasitaemia, faster
than any other antimalarial drug.

This page is restricted. Please Login / Register to view this page.