Medical Articles

Valacyclovir

Oral Anti viral

Description

Valacyclovir is oral antiviral for herpes viruses; it is prodrug that need renal dose adjustment.

Mechanism of action

L‑valyl ester prodrug of acyclovir with improved oral bioavailability.
After conversion to acyclovir, viral thymidine kinase phosphorylates it to acyclovir triphosphate, which competitively inhibits viral DNA polymerase and causes DNA chain termination in HSV‑1, HSV‑2 and VZV.
This page is restricted. Please Login / Register to view this page.

Mechanism of action

L‑valyl ester prodrug of acyclovir with improved oral bioavailability.
After conversion to acyclovir, viral thymidine kinase phosphorylates it to acyclovir triphosphate, which competitively inhibits viral DNA polymerase and causes DNA chain termination in HSV‑1, HSV‑2 and VZV.
This page is restricted. Please Login / Register to view this page.