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Hypoxia-inducible factor (HIF-1α) prolyl hydroxylase inhibitor (PHI)

Description

Oral HIF stabilizer for anemia of chronic kidney disease (CKD). Increases endogenous erythropoietin production by stabilizing HIF-1α, improving hemoglobin without need for ESA injections.

Mechanism of action

Inhibits hypoxia-inducible factor prolyl hydroxylase domain (PHD), preventing HIF-1α degradation. Stabilized HIF-1α increases EPO production in kidneys and iron metabolism, enhancing erythropoiesis.

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Mechanism of action

Inhibits hypoxia-inducible factor prolyl hydroxylase domain (PHD), preventing HIF-1α degradation. Stabilized HIF-1α increases EPO production in kidneys and iron metabolism, enhancing erythropoiesis.

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