First selective ETA-antagonist for chronic kidney disease (CKD) with proteinuria. Reduces blood pressure and proteinuria by blocking endothelin-mediated vasoconstriction and glomerular injury.
Selective blockade of ETA endothelin receptors on vascular smooth muscle and glomerular mesangial cells, reducing vasoconstriction, proteinuria, and renal inflammation. Avoids ETB receptor blockade to preserve endothelial function.
Selective blockade of ETA endothelin receptors on vascular smooth muscle and glomerular mesangial cells, reducing vasoconstriction, proteinuria, and renal inflammation. Avoids ETB receptor blockade to preserve endothelial function.
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