First-in-class APRIL inhibitor for immunoglobulin A nephropathy (IgAN). Reduces proteinuria by targeting B-cell activation factor essential for IgA production and pathogenic immune complex formation.
Selectively binds APRIL (a proliferation-inducing ligand), inhibiting B-cell differentiation and plasma cell survival. Reduces galactose-deficient IgA1 (Gd-IgA1) production, decreasing pathogenic immune complex formation in glomeruli.
Selectively binds APRIL (a proliferation-inducing ligand), inhibiting B-cell differentiation and plasma cell survival. Reduces galactose-deficient IgA1 (Gd-IgA1) production, decreasing pathogenic immune complex formation in glomeruli.
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