First-in-class activin signaling inhibitor (ActRIIA ligand trap) for pulmonary arterial hypertension (PAH). Binds and neutralizes activin A/B ligands to promote right ventricular adaptation.
Recombinant ActRIIA receptor ectodomain acts as ligand trap, binding activin A and B ligands, preventing Smad signaling. Reduces TGF-β superfamily pathway activation, promoting RV hypertrophy adaptation and reducing maladaptive remodeling.
Recombinant ActRIIA receptor ectodomain acts as ligand trap, binding activin A and B ligands, preventing Smad signaling. Reduces TGF-β superfamily pathway activation, promoting RV hypertrophy adaptation and reducing maladaptive remodeling.
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© 2025 The Doctors Platform. All Right Reserved.
