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Tirzepatide

Dual GLP-1/GIP receptor agonist (Incretin mimetic)

Description

First-in-class dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. Approved for type 2 diabetes (Mounjaro) and chronic weight management (Zepbound). Provides superior glycemic control and weight loss vs monotherapy.

Mechanism of action

Agonist at both GLP-1 and GIP receptors, enhancing glucose-dependent insulin secretion, improving beta-cell function, suppressing glucagon, slowing gastric emptying, and promoting satiety. Dual action provides greater efficacy than GLP-1 alone.

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Mechanism of action

Agonist at both GLP-1 and GIP receptors, enhancing glucose-dependent insulin secretion, improving beta-cell function, suppressing glucagon, slowing gastric emptying, and promoting satiety. Dual action provides greater efficacy than GLP-1 alone.

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